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Hormone Therapy for Prostate Cancer

Androgens are male hormones. Androgens such as testosterone are made in the testicles. Prostate cancer cells need androgens to grow. Reducing the amount of androgens in the body or blocking prostate cancer cells from using them can help treat prostate cancer. This therapy does not cure the cancer, but it can help control it. It may be used alone. Or it may be used with radiation therapy to help make this treatment more effective. Read below to learn more about this treatment.

How the therapy is done

Hormone therapy can be done with:

  • LHRH (GnRH) agonists or antagonists. These are medicines that stop the testicles from making androgens. These are injected into a muscle or just under the skin. This is done every few weeks or months. Or they may be given with a small device put under the skin on the inside of the arm. This implant gives a steady dose of medicine over time. LHRH agonists and antagonists are often used with anti-androgens (see below).

  • Anti-androgens. These are medicines that stop cancer cells from using androgens as a way to grow. These come in pill form and are taken by mouth. They are often used along with other forms of hormone therapy.

  • CYP17 inhibitors. These slow the amount of hormones made in prostate cancer cells and other body cells. They are given as pills. They are often used along with other forms of hormone therapy.

  • Other medicines. These may include corticosteroids, estrogens, or anti-fungal medicines. These can also help lower the levels of androgens in the body. They are used less often than the medicines listed above.

  • Orchiectomy. This is surgery to remove the testicles. This stops the body from making most androgens. Artificial (prosthetic) testicles can be placed afterward to give the look of real testicles.

Possible side effects 

Side effects are similar for most types of hormone therapy, but they can vary a bit between medicines. Possible side effects can include:

  • Sudden increase in body heat (hot flashes)

  • Tiredness

  • Less interest in sex

  • Inability to get or keep an erection

  • Decrease in size of penis and testicles

  • Changes in facial hair

  • Mood changes, such as depression, irritability, or anxiety

  • Trouble with memory and concentration

  • Loss of muscle

  • Diarrhea

  • Nausea

  • Weight gain

  • Breast-area tenderness or growth

  • Low red blood cell count (anemia)

  • Hair loss

  • Bone thinning (osteoporosis)

  • Increased risk of heart disease, stroke, and diabetes

Coping with side effects

Some of the side effects are temporary. Others are more long-lasting. This depends on the type of hormone therapy used, and how it affects your body. Most side effects of orchiectomy are permanent. Your health care provider can tell you more. To help cope with side effects, try the tips below.

  • Talk to your health care provider about your symptoms. He or she may prescribe medicines that can help you feel better and reduce problems.

  • If you have hot flashes, don’t take hot showers. Don’t use hot tubs or saunas.

  • Don’t eat spicy food or drink alcohol. Don’t have caffeine.

  • Get regular physical activity.

  • Eat a healthy diet.

  • Keep mentally active.

  • Work with your partner to manage sexual changes.

  • Try counseling or support groups.

Follow-up care

During the course of your treatment, you’ll have regular visits with your health care provider. You may also have tests. These let your health care provider check your health and see how well the treatment is working. After treatment ends, you and your health care provider will discuss the results. You’ll also discuss whether you need additional cancer treatments.


For more information about cancer and its treatment, visit the websites listed below:

Online Medical Reviewer: Alteri, Rick, MD
Online Medical Reviewer: Cunningham, Louise, RN
Last Review Date: 3/30/2015
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